"However, rather than definitively settling that debate, this study underscores the intricate effects of alcohol consumption on cardiovascular health and generates a useful hypothesis for future investigations," Liu says.įor the study, the researchers examined blood samples to measure the association between the cumulative average consumption over 20 years of beer, wine, and liquor and 211 metabolites among 2,428 Framingham Heart Study Offspring Study participants, who are the children of participants in the long-running Boston University-based Framingham Heart Study. "Because the majority of our study participants are moderate alcohol consumers, our findings contribute to the ongoing discussion about the relationship between moderate alcohol drinking and heart health." "The study findings demonstrate that alcohol consumption may trigger changes of our metabolomic profiles, potentially yielding both beneficial and harmful outcomes," says Chunyu Liu, assistant professor of biostatistics at BUSPH and co-corresponding/co-senior author of the study along with Jiantao Ma, assistant professor in the Division of Nutrition Epidemiology and Data Science at the Friedman School. The findings provide a better understanding of the molecular pathway of long-term alcohol consumption and highlight the need for and direction of further research on these metabolites to inform targeted prevention and treatment of alcohol-related CVD. The researchers observed a total of 60 alcohol consumption-related metabolites, identifying seven circulating metabolites that link long-term moderate alcohol consumption with an increased risk of CVD, and three circulating metabolites that link this same drinking pattern with a lower risk of CVD. Published in the journal BMC Medicine, the study found that alcohol consumption may have counteractive effects on CVD risk, depending on the biological presence of certain circulating metabolites-molecules that are produced during or after a substance is metabolized and studied as biomarkers of many diseases.
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